Yung 1..10

drugs that could be used in conjunction with surgery to treat this debilitating neurological disease. receptor may be new therapeutic targets for developing 1 the fetal mice. These results suggest that LPA and its LPA receptor antagonist blocked the ability of LPA to induce hydrocephalus in 1 came with their demonstration that an LPA receptor, they were unable to induce hydrocephalus. The key finding 1 experiments with fetal mice lacking the LPA receptor by these cells. When the researchers repeated their 1 this mislocalization depended on expression of the LPA resulted in altered adhesion and mislocalization of neural progenitor cells along the surface of the ventricles and that LPA how an increase in LPA might affect cortical development and lead to hydrocephalus. They show that injection of cerebral ventricles of fetal mice in utero, the mice did indeed develop severe hydrocephalus. The authors wondered might be involved in the development of hydrocephalus. When they injected a solution containing LPA into the investigators reasoned that LPA, a blood-borne lipid that is known to be important for the developing cerebral cortex, hydrocephalus, with animals displaying enlarged heads, dilated ventricles, and thinning of the cortex. The different time points. Injection of serum or plasma but not red blood cells induced CSF accumulation and utero at 13.5 days of gestation. The animals were then assessed prenatally 1 or 5 days later or postnatally at several The authors injected serum, plasma, or red blood cells into the cerebral ventricles of the brains of fetal mice in hydrocephalus does not develop in fetal mice. by a receptor antagonist, that 1 hydrocephalus and show that when LPA is prevented from binding to its receptor LPA they developed. They identify a blood-borne lipid called lysophosphatidic acid (LPA) as a potential cause of set out to investigate which factors in blood trigger hydrocephalus using an in vivo fetal mouse model that et al. Yung ventricles, but this approach only relieves intracranial pressure and does not solve the root cause of the disorder. cerebral The most common treatment is surgical insertion of an intraventricular shunt that drains excess CSF from the fetus, suggesting that factors or components in blood may trigger development of this severe neurological disorder. in 1500 live births. One apparent cause of hydrocephalus is bleeding into the cerebral ventricles or brain tissue of the 1 ventricles during fetal development and is one of the most common neurological disorders of newborns, occurring in Hydrocephalus or ''water on the brain'' is caused by accumulation of cerebrospinal fluid (CSF) in the cerebral Is the Cause of Hydrocephalus Blood Simple?